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Treatment of Chronic Inflammatory Demyelinating Polyneuropathy with Intravenous Immunoglobulin Ann Neurol 30:104-106, Cornblath,D.R.,et al, 1991 See this aricle in Pubmed Article Abstract Chronic inflammatory demyelinating polyneuropathy is an immune-mediated demyelinating peripheral neuropathy usually treated with immunosuppressants.We reviewed our experience treating 15 patients(9 men,6 women)with intravenous immunoglobulin.Six patients were on other therapies at the time of intravenous immunoglobulin infusions(4,prednisone;2, prednisone and azathioprine).The dose of intravenous immunoglobulin was either 0.3 or 0.4 gm/kg/day for 4 to 5 days.Transient fever occurred in 1 patient.Subjectively improvement in sensory symptoms was reported by almost all patients.Objectively improvements in strength or functional tasks occurred in only 3 patients,a man with human immunodeficiency virus infection,a 14-year-old girl.and a woman with immunoglobulin G kappa para- protein.Our results suggest that individual patients may respond to intravenous immunoglobulin therapy.A multicenter controlled trial is needed to ascess properly the role of intravenous immunoglobulin therapy in patients with chronic inflammatory demyelinating polyneuropathy.

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(click to filter results - removes previous filter) gammaglobulin therapy,intravenous neuropathy neuropathy,peripheral,treatment polyneuropathy polyneuropathy,chronic inflammatory demyelinating treatment of neurologic disorder

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